The Indoor Environment Quality Observatory (OQEI), run by the Scientific and Technical Centre for Building (CSTB) and the French Agency for Food, Environmental and Occupational Health & Safety (ANSES), is presenting the first results from the Second National Housing Campaign (CNL2), which has documented changes in air quality in French homes since the previous campaign (2003-2005). More than 170 pollutants were measured. This first report from the CNL2 covers results relating to volatile organic compounds (VOCs) and semi-volatile organic compounds (SVOCs), nitrogen dioxide (NO2), fine particulate matter (PM2.5) and radon. The results of this study, which was carried out by the CSTB, have been validated by the OQEI's Scientific Board.