New genomic techniques (NGTs) offer a vast range of applications, especially in the breeding of cultivated plants. Similar to genetically modified organisms (GMOs), but nevertheless distinct from transgenic plants, these applications require careful consideration with a view to their possible arrival on the European market. Within the scope of its missions, ANSES conducted an expert appraisal of the challenges associated with these NGTs in order to provide the authorities and stakeholders with insights for the current discussions on changes to the European GMO framework. The Agency proposed adapting the assessment of these plants on a case-by-case basis, using a graduated approach, and recommended a comprehensive monitoring scheme. In addition to the health challenges, ANSES also identified various socio-economic motivations and concerns associated with NGTs in agriculture, and called for future decisions to be based on a democratic debate that goes beyond the risks and considers all the issues at stake.